Reddit; Wechat; To the Editor, We read with interest the papers by Brenner 1 and Cimolai 2 regarding the therapeutic potential of memantine for coronavirus disease 2019 (COVID‐19). From experience, sublingual seems to have the fastest onset, and reasonable bioavailability, but the taste is rather unpleasant. It is less preferred than acetylcholinesterase inhibitors such as donepezil. And anything else you might like to add. Memantine seems to work in 'waves' similar to that of LSD, although intervals are somewhat shorter between swells. The mean age of patients who were receiving memantine and placebo was about 34.7 ± 4.48 and 31.5 ± 7.4 years, respectively. We promote harm reduction and fight against the drugs stigma. From my personal experience, however, there is little chance of mania or anxiety even in high doses especially in comparison to DXM, and throughout the entire trip you will have a sense of contentment unwavering. I've come to find that most chemicals go: I started taking memantine a few months ago, and have experimented a few times with higher recreational doses. The results have shown a significant difference in the behavior and attention deficit between the two groups treated with memantine and placebo during 6 weeks (p < 0.001). Good, comprehensive guide/advice. Get your prescription refilled before you run out of medicine completely. Can you elaborate more on how it helped your depression? Memantine is on my bucket list, I really hope I get the chance to try it someday. Make sure you follow the RULES. If you over shoot it, it's a very long time to endure it. Keep the liquid medicine bottle tightly closed with the cap provided. I'd figured they would've found cough medicines that work just as well w/o being psychoactive during the War on Drugs but nah lol. Is it possible to hole on? Euphoria is more and more present, but loss of fine and gross motor control becomes more apparent. Memantine 20 mg compared to placebo for mild AD (MMSE 20‐23) observed case (OC) ‐ six‐month studies for dementia. This means that for memantine to bind, the neuron has to depolarize, and open to clear the magnesium block. Memantine is substituted with a methyl carbon at both R3 and R5; it contains an amine substitution at R1. It's clean feeling, compared to DXM. However my memory lapses happen every 2 weeks or so and only for a short period. Auditory effects are negligible on Memantine, an enhanced appreciation for music is apparent, but no more than a slight ringing in the ears will be noticed (Memantine has shown efficacy in treatment for tinnitus so who knows what's going on there). OK just ingested 30 mg, we'll see, I don't want a full blown recreational high but I guess 30mg is good because many drugs just get my anxiety worse. Above 100mg and you'll likely not be moving from your bed/couch very often, although it is possible. Just remember that there is no 100% safe drug use. Super Sour Ketamine is what I would describe the taste as. Structures and voids are very apparent in low light and I would argue go beyond level 4. 3 McShane R, Westby MJ, Roberts E, Minakaran N, Schneider L, Farrimond LE, Maayan N, Ware J, Debarros J. Memantine as a treatment for dementia, Dementia and Cognitive Improvement Group. Both the research  and anecdotal reports  recount as much. Population: mild Alzheimer's disease Intervention: memantine 20 mg Comparison: placebo . The new dementia NICE guidelines published in June 2018 state that we should consider memantine for patients with moderate Alzheimer’s Disease and offer memantine for people with severe Alzheimer’s Disease, and if the person is already Memantine is commonly used for the treatment of moderate-to-severe Alzheimer's disease. After I've eaten and sat down to begun browsing reddit, the fact I've taken the Memantine has almost completely been forgotten by me, I begin to feel a bit spacey and calm. Memantine, or 3,5-dimethyladamantan-1-amine, is a man-made molecule classified as a substituted adamantane derivative. Don't dismiss it based on the lack of information that exists on here and elsewhere currently on the internet. Cheers man, I'll put it to good use. You will be given a small dose when you first start treatment. Not using is always safer. Press question mark to learn the rest of the keyboard shortcuts. Although the half life of Memantine in your body is around 80 hours, the subjective effects are somewhere closer between 12-24 hours, and can be reduced with the acidification of your urine, increasing it's excretion rate. I have a few questions regarding its effects however. The peak is reached about 2-3 hours after ingestion and will plateau for another 10 hours before slowly diminishing. Although I cannot back up this claim with empirical evidence, Memantine is potentiated by Cannabis. I have just awoken at 90+ hours, and I think I'm finally pretty much back to baseline. Mild potentiaition occurs but otherwise I haven't found a way to describe exactly what changes, it is a fairly unique experience. I'm clumsy and stumbling a bit, but I'm able to use a keyboard and phone just fine. Memantine isn't very long term memory impairing, in comparison to DXM, or even Ketamine, but short term memory does seem to suffer a bit and you can lose trains of thought quite easily at high doses. Take one dose every day, at the same time of day each day. Dr Andrade takes a closer look at the methods the authors used and the studies they included to weigh the merits of their conclusions. I light up a cigarette, like after most meals, and notice the slow whisps of smoke dancing around my hand, this is when I remembered about the Memantine, about 2 hours after taking the dose. I was blown away the first time I tried Memantine with weed, it is comparable to DXM with and without weed. As many comparisons to other common compounds as possible would be extremely useful for fleshing out the subjective effects section. A recent meta-analysis found substantial benefits of memantine in treating obsessive-compulsive disorder. Results were inconclusive because of studies with poor levels of … Although doses will vary from person to person, I believe most beginner users would do well with 50mg as a starting recreational dose. Memantine was not effective at reducing cognitive deficits, and patients who tried memantine had more adverse effects such as fatigue . Do you have any previous experience with dissociatives, and if so how do they compare? You can drink cranberry juice to acidify your urine throughout your trip to shorten it's duration, avoid citrus and other foods that basify your urine. Memantine is a medication used to treat moderate-to-severe Alzheimer's disease. Visually fairly similar to ketamine, but more controllable. Memantine Dosage. Memantine is great. Please comment back on what your experience was like at that dose though. Memantine is an uncompetitive NMDA receptor antagonist, and subjectively feels somewhere between Ketamine & DXM (perhaps closer to one of PCP analogues, but I can't comment on their subjective effects) with a longer duration than either. There are over-the-counter medications available to acidify the urine too; for example, pills containing methionine, which is used to prevent bladder infections.' That way, memantine is eliminated 7-10 times faster. You need to leave yourself at least 12 hours before you want to sleep before dosing. Seems to help my short term memory. That being said, Memantine is a beautiful drug. The half-life really makes this unsuited for recreational use imo. In addition, alcohol, opiates, stimulants and other dissociatives should be avoided when on recreational doses of Memantine as unwanted side effects, such as increased heart rates, respiratory depression, nausea and in worst case death, may occur. Your doctor will need to check your progress while you are using memantine. I had structures I could interact with in the 3D world, put my arm behind and have my vision of my arm disappear but still being fully aware of the room I was in. Well dang, I'll have to figure out what my dose would be like (considering I have a dissociative tolerance currently). Adding the Alzheimer drug memantine to a selective serotonin reuptake inhibitor (SSRI) may improve depressive symptoms, as well as apathy, anxiety, and cognitive function, in older patients. I've never seen a new user format an article so legitimiately in accordance with the rest of the site. Psychonautwiki founder here, you did an amazing job on the mementine article dude. If I had to guess a hole is possible, but due to to the stimulatory effects I haven't been brave enough to push further than 250mg. When in doubt, DON'T. Thanks! Memantine seems to work in 'waves' similar to that of LSD, although intervals are somewhat shorter between swells. The one time I've combined LSD and a recreational dose of Memantine was one of the single most euphoric experiences I've ever had. This is a risk reduction resource. The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. How much does it help? Memantine the Unknown Drug Tolerance Prevention Chemical Memantine has had been a well kept secret for drug tolerance prevention. Furthermore, memantine caused short-term worsening of neurologic symptoms in MS, thereby exacerbating the cognitive deficits [ 41 ]. I feel very clear-headed on memantine. Pharms - Memantine (309), Sleep Deprivation (140) : General (1), First Times (2), Hangover / Days After (46), Multi-Day Experience (13), Various (28) COPYRIGHTS: All reports are copyright Erowid and you agree not to download or analyze the report data without … Deprescribing ChEIs and memantine through shared decision making with individuals and their caregivers by: determining their treatment goals; discussing benefits and harms of continuing and ceasing medication, from the start of therapy and throughout; and engaging them in monitoring after discontinuation, while informing carers that the individual will continue to decline after discontinuation. You can take memantine either before or after meals. Don't re-dose thinking it wasn't a high enough dose, you'll regret the compounding effects of multiple doses. Less introspective. It's heavily memory impairing for a few minutes, and fairly confusing at high doses. Namenda (memantine): “My PCP put me on Namenda to supplement my Aricept for Alzheimer's Disease . Functional enough to play games like Overwatch and keep up with it without any struggle. Although I cannot back up this claim with empirical evidence, Memantine is potentiated by Cannabis. I may be an outlier with medical significance but if there's even one other person who finds it as beneficial as I do then I'm more than happy to share whatever information I can on Memantine. I'm super happy I'm not the only one around here using it like this. Memantine also is a Dopamine D2 agonist, a non-competitive Serotonin 5-HT3 antagonist, a non-competitive nAChRs antagonist with similar potencies to NMDA antagonism and the Sigma σ1 receptor with potentially negligible activity. It feels almost like you can will yourself in and out of consciousness at that dose. No sweating, over heating, or other common effects from stimulants, possibly due to how mild it's stimulant effects are (for me). After I've eaten and sat down to begun browsing reddit, the fact I've taken the Memantine has almost completely been forgotten by me, I begin to feel a bit spacey and calm. However, the drug does not cure Alzheimer’s. Ketamine: Much less sedating. The Memantine market has witnessed growth from USD XX million to USD XX million from 2014 to 2019. YOU WILL BE BANNED FOR ASKING OR PROVIDING DRUG OR PARAPHERNALIA SOURCES, whether illegal or legal. Whereas on DXM, it might be too hard to try to play a game. 1. I could see some thereputic use in this because of it's functionality and long half life. Hey guys, some of you may recognise me as that guy who goes on and on about Memantine's recreational value whenever given the chance, but up until now I didn't really have a way to explain how one might approach Memantine if they were interested in it's recreational potential. Memantine changed my life, therapeutic use fixed my depression, stopped me from compulsively using Ketamine to treat it, and has given me a quality of life I had only dreamed of, and I get to trip on it once in a while too. Could you describe to me in as much detail as possible how it feels in comparison to traditional dissociatives such as ketamine, mxe and dxm? Nice report. Preface. Memantine for dementia – what, why, who and when? Memantine is a cough suppressant as well, so take note of how big your bongs are packed because you wont notice how big it is while pulling it. Memantine helps to ease the symptoms of dementia in Alzheimer's disease. It is a long acting NMDA receptor antagonist that binds to an open channel binding site. Some gastro-intestinal disturbances could be possible however, due to D2 agonism, there's not much info on this. I can't explain much further, simply because I can't remember what happens when I do it. The memantine dosage will differ based on the use case. In this study, we evaluated whether a combination of memantine with melatonin, administered for 32 days in drinking water, was more effective than either drug alone with respect to Aβ aggregates, neuroinflammation and cognition in the double transgenic APP/PS1 (5xFAD) mouse model of AD. Dosing Memantine is simple, but requires some planning and forethought. The visuals and euphoria become much more intense and interesting after weed is smoked. Its core structure is adamantane, a diamondoid of four interlocked cyclohexane rings in a stable 3-dimensional lattice conformation. With the CAGR of X.X%, this market is estimated to reach USD XX million in 2026. I have used ketamine in the past with the intention of helping depression and it was very pleasant at the time. The best part of Memantine is that it's available on the clearnet, although you'll have to find sources yourselves. 85mg Memantine Trip Report from January 2019 (edited, repost) Experience Report. This includes: URLs, markets, PMs, etc. (Yes, citric acid causes your urine to become more alkaline, I learnt the hard way) A single oral dose is highly recommended. The physical euphoria is apparent, dissociation is only mild, and its still quite easy to stay focused and motivated. TL;DR: Memantine has a high potential for recreational use. Although heavy doses are still somewhat forgiving, in my experience, I wouldn't start with anything higher than 100mg, even with dissociative tolerance, purely based on duration. A sub for discussing all uses of Memantine, from therapeutic to recreational. Treatment should only be continued if beneficial effects are seen. It was first developed in the 1960s for the treatment of diabetes. How long do the effects last? Insufflation works, has a slightly faster onset but is fairly painful. I want to bring it to light as the amazing drug it is. Although there is moderate-certainty evidence that fewer people taking memantine experience agitation as an adverse event: RR 0.81 (95% CI 0.66 to 0.99) (25 fewer people per 1000, 95% CI 1 to 44 fewer), there is also moderate-certainty evidence, from three additional studies, suggesting that memantine is not beneficial as a treatment for agitation (e.g. Memantine is a moderate affinity, uncompetitive NMDA receptor antagonist with strong voltage-dependency and fast kinetics. Duration is manageable with correct dose amount and timing. Never heard of this drug before. It has a pretty clear anxiolytic effect on me. It doesn't appear in any feeds, and anyone with a direct link to it will see a message like this one. I'm on 20mg daily for mood stabilisation. Once this is tidied up a little i will make it a featured article on the mainpage and post it to our facebook group. New comments cannot be posted and votes cannot be cast, More posts from the MemantineHCl community. If it isn't apparent guys, I have a lot of spare time. Memantine is een geneesmiddel dat geregistreerd is voor de behandeling van patiënten met een matige tot ernstige vorm van de ziekte van Alzheimer.Het behandelt de oorzaak van de ziekte niet maar het laat toe dat patiënten misschien wat langer zelfstandig kunnen functioneren. Then memantine is pulled into the channel to its binding site. Additional information on Memantine can be found: https://psychonautwiki.org/wiki/Memantine, https://www.erowid.org/pharms/memantine/memantine.shtml, Edit: If you've found this post recently, I've made a follow up post, answering some of the frequently asked questions I was receiving after making this post HERE. Memantine seems less debilitating than that of Ketamine or DXM. I'm not sure on what specific details your looking for but I can answer in more detail whatever questions you ask. 30mg seems to be barely a threshold dose. Common side effects … Depth perception is by far the biggest impacted sense, and in low light settings will make the room you're in feel like its constantly moving between being a cathedral in size to a shoebox. If you're aiming for a “K-hole” like experience, then I would not recommend Memantine, its difficult to achieve, if at all possible, and if it were, the duration of it would be far beyond reasonable. It is taken by mouth. In high doses I found memantine to be a somewhat generic dissociative although it did have some psychedelic style visuals which was a little unusual. Seeing as Erowid has limited information on Memantine this guide aims to add another resource out there. I light up a cigarette, like after most meals, and notice the slow whisps of smoke dancing around my hand, this is when I remembered about the Memantine, about 2 hours after taking the dose. Great write up, thanks for the info! I don't think it's for everyone, but it certainly has enough merit for those who like dissociatives to try. Its name is derived from its structure; 3,5-dimethyladamantan-1-amine. I'll explain how some of these play a role in the subjective experience down further. Onset is between 45-180 minutes (As short as 30 minutes sublingually, from experience), so you'll be sitting around for a bit waiting for it to kick in. User Reviews for Memantine. 2019 One meta-analysis showed that there was a significant improvement in cognitive function in AD patients who took memantine. One interesting memantine side effect includes higher libido. This review summarizes existing hypotheses on the mechanism of action (MOA) of memantine in an attempt to understand how the accepted interaction with NMDA receptors could allow memantine to provide both neuroprotection and reverse deficits in … Thanks again dude. When it is working I can think clearly. I smoke tobacco bongs regularly so I seek out heavy nicotine rushes, but when on Memantine most of the rush is gone and it turns into a more deliriant-like experience. Ive had minimal unwanted physical side effects. Due to its antagonism of the N-methyl-d-aspartate (NMDA) receptor, which has been shown to block rewarding and reinforcing effects of morphine, memantine has been investigated for potential utilization in … It's worth noting I have never experienced nausea from Memantine, possibly due to the 5-HT3 antagonism. In 2003, the FDA approved Memantine for the treatment of both severe and moderate Alzheimer’s disease. Upwards of 100mg and the dissociation becomes much more apparent, visuals will take form in the way of perceptual changes; depth perception alteration, visual acuity and colour enhancements are some of the most apparent effects. For those who want to use memantine for treating … Results: From 2010 to November 2019, 307 topics citing memantine were identified on reddit.com and 136 users experiences extracted from the topics were recorded. Press J to jump to the feed. 278 Memantine blocks the extensive activity of NMDA receptors but does not accumulate to interfere with normal synaptic transmission, and hence no disruption of normal physiological activity. Low light settings let the visuals take hold much better and in complete darkness even 100mg may produce visuals on par with high Ketamine doses (for me high constitutes 200mg+), in a respective setting. Sourcing drugs is NOT allowed here! ... T+03:00 Texted my friend for a bit, browsed Reddit, watched YouTube. The first week I was trialing it, I remember comparing the effects to that of Valium to my doctor and he seemed surprised by how well it was working. Looks like you're using new Reddit on an old browser. To me I'd describe it as similar physical euphoria to a high 2nd plateau/low 3rd plateau DXM, and similar emotional effects, but without the mindfuck that DXM can cause. It's euphoric, mildly stimulating, and very clear headed compared to other dissociatives. 43% of those users who reviewed Memantine reported a positive effect, while 41% reported a negative effect. Sweet write up, it sounds like an interesting drug worth experiencing. Sorry, this post was deleted by the person who originally posted it. I tried memantine a few times and enjoyed it enough, but itâs a weird one, isnât it? Use memantine regularly to get the most benefit. And for the most part I'm perfectly functional cognivitely. Memantine is used for treatment of moderate-to-severe stage of AD. the headspace has much less "static" noise, even compared to being sober. It produces an amazing unique physical euphoria, even in low doses, it's very clear headed, and the visuals are somewhat unique, although I cannot compare it to dissociatives other than Ketamine, DXM & Nitrous. However, due to ketamine's difficultly to find, expense, and potential damage to the bladder, it isn't something I can regularly use. The review covers memantine studies in postherpetic neuralgia, diabetic pain, postoperative pain, complex regional pain syndrome, chronic phantom limb pain, opioid‐refractory pain and fibromyalgia. What is it with cough suppressants getting us high as shit? I haven't pushed the limits enough to definitively say it exists. Tobacco (most likely the nicotine, but I haven't ingested pure nicotine) also changes the subjective experience of Memantine, although only briefly. Also known as: Namenda, Namenda XR Memantine has an average rating of 5.3 out of 10 from a total of 55 ratings on Drugs.com. Memantine, 3-MEO-PCE, LSD, 4-AcO-MiPT, 4-HO-MET, 2C-C, Clonazepam & Aripiprazole: Adventures in NMDA Receptor Antagonism: viscosity: Memantine & DXM: Just the Kick in the Teeth I Was Looking For: 180OnTheDVP: Memantine & Nitrous Oxide: Beyond Tollerance Reduction: Clyde T. And personally I enjoy it a lot. Score with placebo (median) Mean improvement in change score between memantine and placebo. The one time I've combined LSD and a recreational dose of Memantine was one of the single most euphoric experiences I've ever had. A short intro to Memantine. Continuous outcomes. But if you like dissociatives like DXM/Ketamine, I think it's definitely worth trying. With that being said, I don't think memantine would be an enjoyable experience for everyone. Facebook group a beautiful drug at R1 at reducing cognitive deficits [ ]... 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